Datasheet > SC-23121

SC-23121

更新时间： 2024-09-30 22:22:19

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Rac 2 (L-10): sc-23121

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Santa Cruz Biotechnology, Inc.

Rac 2 (L-10): sc-23121

BACKGROUND

BACKGROUND REFERENCES

A large number of low molecular weight, GTP binding proteins of

the Ras superfamily have been identified (1). These proteins regulate

many fundamental processes in all eukaryotic cells such as growth,

vesicle traffic and cytoskeletal organization. GTPase-activating

proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of

Ras-related proteins, resulting in downregulation of their active

form (2-6). Two proteins in this family, Rac 1 and Rac 2, are

92% identical and share GTP binding and GTP hydrolysis motifs

with other members of the Ras superfamily (7,8). Rac 1 is

expressed in a large number of different cell types. Rac 2 is

primarily expressed only in myeloid cells (8) and has been reported

to be a regulatory component of the human neutrophil NADPH

oxidase (9).

1. Hall, A. 1990. The cellular functions of small GTP-binding

proteins. Science 249: 636-640.

2. Trahey, M. and McCormick, F. 1987. A cytoplasmic protein

stimulates normal N-ras p21 GTPase, but does not affect

oncogenic mutants. Science 238: 542-545.

3. Martin, G.A., Viskochil, D., Bollag, G., McCabe, P.C.,

Crosier, W.J., Haubruck, H., Conroy, L., Clark, R.,

O’Connell, P., Cawthon, R.M., Innis, M.A., and McCormick, F.

1990. The GAP-related domain of the neurofibromatosis type 1

gene product interacts with ras p21. Cell 63: 843-849.

4. Ballester, R.M., Marchuk, D., Boguski, M., Saulino, A.,

Letcher, R., Wigler, M., and Collins, F. 1990. The NF1 locus

encodes a protein functionally related to mammalian GAP and

yeast IRA proteins. Cell 63: 851-859.

SOURCE

Rac 2 (L-10) is an affinity purified goat polyclonal antibody raised

against a peptide mapping near the carboxy terminus of Rac 2 of

human origin.

5. Xu, G., Lin, B., Tanaka, K., Dunn, D., Wood, D.,

Gesteland, R., White, R., Weiss, R., and Tamanoi, F. 1990. The

catalytic domain of the neurofibromatosis type 1 gene product

stimulates ras GTPase and complements ira mutants of S.

cerevisiae. Cell 63: 835-841.

PRODUCT

Each vial contains 200 µg IgG in 1.0 ml PBS containing

0.1% sodium azide and 0.2% gelatin.

6. Diekmann, D., Brill, S., Garrett, M.D., Totty, N., Hsuan, J.,

Monfries, C., Hall, C., Lim, L. and Hall, A. 1991. Bcr encodes a

Blocking peptide is available for competition studies (sc-23121 P)

(100 µg peptide in 0.5 ml PBS with 0.1% sodium azide and

100 µg BSA).

rac

GTPase-activating protein for p21 . Nature 351: 400-402.

7. Sewell, J.L. and Kahn, R.A. 1988. Sequences of the bovine and

yeast ADP-ribosylation factor and comparison to other

GTP-binding proteins. Proc. Natl. Acad. Sci. USA 85: 4620-4624.

SPECIFICITY

8. Didsbury, J., Weber, R.F., Bokoch, G.M., Evans, T. and

Snyderman, R. 1989. Rac, a novel ras-related family of proteins

that are botulinum toxin substrates. J. Biol. Chem.

264: 16378-16382.

Rac 2 (L-10) is recommended for the detection of Rac 2 of mouse,

rat and human origin by Western blotting and immunohisto-

chemistry.

Recommended dilution range for Western blot analysis:

1:100–1:1000. Recommended starting dilution: 1:100.

9. Knaus, U.G., Heyworth, P.G., Evans, T., Curnutte, J.T., and

Bokoch, G.M. 1991. Regulation of phagocyte oxygen radical

production by the GTP-binding protein Rac2. Science

254: 1512-1515.

STORAGE

Store at 4° C, do not freeze; stable for one year from the date of

shipment.

RESEARCH USE

For product citations, please visit our website at www.scbt.com

For research use only, not for use in diagnostic procedures.

U.S. 1.800.457.3801 • 831.457.3800 • fax 831.457.3801 • Europe 800 4573 8000 • 49 (0)6221 4503 0 • fax 49 (0)6221 4503 45 • www.scbt.com

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与SC-23121相关器件

型号	品牌	获取价格	描述	数据表
SC23-12CGKWA	KINGBRIGHT	获取价格	7 SEG NUMERIC DISPLAY, GREEN, 56.9mm, ROHS COMPLIANT PACKAGE-10
SC23-12EWA	KINGBRIGHT	获取价格	Standard-Displays
SC23-12EWA_11	KINGBRIGHT	获取价格	57mm (2.3INCH) SINGLE DIGIT NUMERIC DISPLAY
SC23-12GWA	KINGBRIGHT	获取价格	Standard-Displays
SC23-12GWA_11	KINGBRIGHT	获取价格	57mm (2.3INCH) SINGLE DIGIT NUMERIC DISPLAY
SC23-12HWA	KINGBRIGHT	获取价格	Standard-Displays
SC23-12SEKWA	KINGBRIGHT	获取价格	7 SEG NUMERIC DISPLAY, SUPER BRIGHT ORANGE, 56.9mm, ROHS COMPLIANT PACKAGE-10
SC23-12SRWA	KINGBRIGHT	获取价格	56.9mm (2.3INCH) SINGLE DIGIT NUMERIC DISPLAY
SC23-12SURKWA	KINGBRIGHT	获取价格	Smart/Normal 7 Seg Numeric LED Display, Hyper Red, 56.9mm, ROHS COMPLIANT PACKAGE-10
SC23-12SYKWA	KINGBRIGHT	获取价格	7 SEG NUMERIC DISPLAY, SUPER BRIGHT YELLOW, 56.9mm, ROHS COMPLIANT PACKAGE-10

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