Datasheet > G9963A

G9963A

更新时间： 2024-11-12 01:22:43

品牌	Logo	应用领域
惠普 - HP		/
页数	文件大小	规格书
2页	234K
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NGS Disease Research Panels

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G9963A 数据手册

NGS Disease Research Panels

ClearSeq AML^HS

Access Targets for Acute Myeloid Leukemia (AML) Research

Now with Molecular Barcodes!

Overview

Beneﬁts

Acute myeloid leukemia (AML) is the most common myeloid neoplasm affecting

adults and the role of chromosomal structural variations in its molecular pathogenesis

have been well-established.¹In recent years, next generation sequencing has led to

a revolution in the study of hematological malignancies and shown that mutations

and indels play an essential part in the pathogenesis of AML.

Expert-Deﬁned Content

– Designed in collaboration with

Dr. Robert Ohgami and Dr. Daniel

Arber at Stanford University

– Targets 20 key genes frequently

mutated in AML

The ClearSeq AML was designed in collaboration with Dr. Robert Ohgami and Dr.

Daniel Arber at Stanford University. It targets 48 selected exons in 20 genes found

to be commonly mutated in AML and to be associated with myelodysplastic

syndromes and myeloproliferative neoplasms.

Premium Performance You Can Trust

– Provides 99.9% design coverage

of targeted exons

The identiﬁcation of rare variants, such as those in heterogeneous tumor samples,

can be practically limited by the error rate associated with the sequencing process

itself.²The ClearSeq AML^HSis an enhanced, high-sensitivity version of ClearSeq

AML that addresses this limitation. Molecular barcodes have been incorporated to

increase the accuracy of variant calls by allowing users to identify and remove false

positive calls due to PCR and sequencing artifacts. It also has greater uniformity of

coverage due to the addition of more overlapping probes in target genes, increasing

the coverage of targeted regions to 99.4% at 20x read depth (Figure 1). Finally, the

product supports DNA input of 50 ng compared with 200 ng input DNA required by

the original kit.

– Conﬁdently discern variants of very

low frequency, down to 0.5%

– Library-prep free target enrichment

in six hours

Comprehensive Workflow Solution

– Get from raw data to mutation

report in 3 simple steps using

SureCall analysis software

– Obtain all reagents for sample

preparation, QC and automation

tools from one trusted partner

More Accurate and Sensitive Variant Calling

The ClearSeq AML^HSincorporates HaloPlex^HStechnology, which is an amplicon-

based, NGS sample preparation method that employs molecular barcodes to

enable detection of variant allele frequencies at below 1%.³Molecular barcodes

ꢀene ꢁist ꢂtargeted eꢃonsꢄ

ꢆꢇꢈꢁ1 12

ꢉꢏꢐ2 8, 1ꢀ, 18

Fꢁꢊꢋ 14, 20

Mꢅꢁ

ꢇFꢋB1 13–15, 1ꢀ

ꢇRꢇF2 1

ꢍꢇFꢋR 14, 1ꢀ

NꢅM1 11

NRꢆꢇ 2, 3

RUNꢈ1 3, 4, 8

ꢇꢉꢊBꢅ1 3

www.agilent.com/genomics/AML

ꢍBꢁ

ꢍꢉBꢅꢆ

8, 9

ꢑꢎꢐ1

ꢑꢎꢐ2

ꢊꢉꢊ2 3, 9, 10, 11

ꢊꢅꢌꢋ 5–8

U2ꢆF1 2, 6

ꢎNMꢊꢋꢆ 4, 8, 13, 15, 16, 18

ꢒꢆꢓ2 12, 14

19, 20, 22, 23

中文翻译

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与G9963A相关器件

型号	品牌	获取价格	描述	数据表
G9963B	HP	获取价格	NGS Disease Research Panels
G9965	GMT	获取价格	1.5A Low Dropout Regulator with Enable
G9965-15TGU	GMT	获取价格	1.5A Low Dropout Regulator with Enable
G9965-18TGU	GMT	获取价格	1.5A Low Dropout Regulator with Enable
G9965-25TGU	GMT	获取价格	1.5A Low Dropout Regulator with Enable
G9965-ADJTGU	GMT	获取价格	1.5A Low Dropout Regulator with Enable
G9966	GMT	获取价格	3A Low Dropout Regulator with Enable
G9966-15TGU	GMT	获取价格	3A Low Dropout Regulator with Enable
G9966-18TGU	GMT	获取价格	3A Low Dropout Regulator with Enable
G9966-25TGU	GMT	获取价格	3A Low Dropout Regulator with Enable

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